Enantiopure Peptide-Functionalized Metal鈥揙rganic Frameworks

详细信息    查看全文

• 作者：Jonathan Bonnefoy ; Alexandre Legrand ; Elsje Alessandra Quadrelli ; J茅r么me Canivet ; David Farrusseng
• 刊名：Journal of the American Chemical Society
• 出版年：2015
• 出版时间：July 29, 2015
• 年：2015
• 卷：137
• 期：29
• 页码：9409-9416
• 全文大小：540K
• ISSN：1520-5126

文摘

We present herein the first example of metal鈥搊rganic frameworks postfunctionalized with peptides. Our microwave-assisted postsynthetic modification method yields enantiopure peptides anchored inside MOF cavities. Al-MIL-101-NH₂, In-MIL-68-NH₂, and Zr-UiO-66-NH₂ were chosen as starting platforms. A single amino acid and various oligopeptides are grafted with yields up to 60% after a 30 min microwave-assisted coupling-deprotection sequence. This allows efficient preparation of a library of functional hybrid solids for molecular recognition applications such as sensing, separation, or asymmetric catalysis, as demonstrated here for the chiral aldol reaction.