Verbesinosides A−F, 15,27-Cyclooleanane Saponins from the American Native Plant Verbesina virginica
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- 作者：Wen-Hui Xu ; Melissa R. Jacob ; Ameeta K. Agarwal ; Alice M. Clark ; Zong-Suo Liang ; Xing-Cong Li
- 刊名：Journal of Natural Products
- 出版年：2009
- 出版时间：June 26, 2009
- 年：2009
- 卷：72
- 期：6
- 页码：1022-1027
- 全文大小：127K
- 年卷期：v.72,no.6(June 26, 2009)
- ISSN：1520-6025
文摘
Verbesinosides A−F (1−6), six new 15,27-cyclooleanane-type triterpenoid saponins carrying different aromatic acyl moieties on the aglycon, were isolated from the leaves and flowers of Verbesina virginica. Their structures were established by interpretation of spectroscopic data and chemical methods. The representative major saponin, verbesinoside A (1), has the structure 21-trimethoxybenzoyl 15α,27-cycloolean-12-en-3β,21β-diol-28-oic acid 3-O-β-pan class="smallcaps">d pan>-xylopyranosyl(1→4)-β-pan class="smallcaps">d pan>-xylopyranosyl(1→2)-β-pan class="smallcaps">d pan>-glucopyranoside. This is the first report of triterpenoid saponins possessing the unique 15,27-cyclooleanane skeleton. The anisotropic effects of the aromatic acyl moieties on the triterpenoid skeleton are discussed.