Glucose-Responsive Hybrid Nanoassemblies in Aqueous Solutions: Ordered Phenylboronic Acid within Intermixed Poly(4-hydroxystyrene)-block-poly(ethylene oxide) Block Copolymer

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• 作者：Alicja Matuszewska ; Mariusz Uchman ; Agnieszka Adamczyk-Wo藕niak ; Andrzej Sporzy艅ski ; Stergios Pispas ; Lubom铆r Kov谩膷ik ; Miroslav 艩t臎p谩nek
• 刊名：Biomacromolecules
• 出版年：2015
• 出版时间：December 14, 2015
• 年：2015
• 卷：16
• 期：12
• 页码：3731-3739
• 全文大小：631K
• ISSN：1526-4602

文摘

Coassembly behavior of the double hydrophilic block copolymer poly(4-hydroxystyrene)-block-poly(ethylene oxide) (PHOS鈥揚EO) with three amphiphilic phenylboronic acids (PBA) differing in hydrophobicity, 4-dodecyloxyphenylboronic acid (C12), 4-octyloxyphenylboronic acid (C8), and 4-isobutoxyphenylboronic acid (i-Bu) was studied in alkaline aqueous solutions and in mixtures of NaOH<sub>aqsub>/THF by spin鈥揺cho <sup>1sup>H NMR spectroscopy, dynamic and electrophoretic light scattering, and SAXS. The study reveals that only the coassembly of C12 with PHOS鈥揚EO provides spherical nanoparticles with intermixed PHOS and PEO blocks, containing densely packed C12 micelles. NMR measurements have shown that spatial proximity of PHOS鈥揚EO and C12 leads to the formation of ester bonds between 鈭扥H of PHOS block and hydroxyl groups of 鈭払(OH)<sub>2sub>. Due to the presence of PBA moieties, the release of compounds with 1,2- or 1,3-dihydroxy groups loaded in the coassembled PHOS鈥揚EO/PBA nanoparticles by covalent binding to PBA can be triggered by addition of a surplus of glucose that bind to PBA competitively. The latter feature has been confirmed by fluorescence measurements using Alizarin Red as a model compound. Nanoparticles were proved to exhibit swelling in response to glucose as detected by light scattering.