Total Synthesis of the Chlorinated Marine Natural Product Dysamide B

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• 作者：Amanda C. Durow ; G. Cliona Long ; Susan J. O'Connell ; Christine L. Willis
• 刊名：Organic Letters
• 出版年：2006
• 出版时间：November 9, 2006
• 年：2006
• 卷：8
• 期：23
• 页码：5401 - 5404
• 全文大小：77K
• 年卷期：v.8,no.23(November 9, 2006)
• ISSN：1523-7052

文摘

Two approaches to the synthesis of (2S,4S)-5,5-dichloroleucine are compared, and the parent amino acid was used in the first total synthesisof the polychlorinated marine natural product, dysamide B. A key step was the lead tetraacetate-mediated decarboxylation of an ,-dichloroacid in the presence of 1,4-cyclohexadiene to generate the dichloromethyl group.