The Synthesis of Certain Phomentrioloxin A Analogues and Their Evaluation as Herbicidal Agents
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- 作者：Ehab S. Taher ; Prue Guest ; Amanda Benton ; Xinghua Ma ; Martin G. BanwellAnthony C. Willis ; Tobias Seiser ; Trevor W. Newton ; Johannes Hutzler
- 刊名：Journal of Organic Chemistry
- 出版年：2017
- 出版时间：January 6, 2017
- 年：2017
- 卷：82
- 期：1
- 页码：211-233
- 全文大小：973K
- ISSN：1520-6904
文摘
A series of 28 analogues of the phytotoxic geranylcyclohexentriol (−)-phomentrioloxin A (1) has been synthesized through cross-couplings of various enantiomerically pure haloconduritols or certain deoxygenated derivatives with either terminal alkynes or borylated alkenes. Some of these analogues display modest herbicidal activities, and physiological profiling studies suggest that analogue 4 inhibits photosystem II in isolated thylakoids in vitro.