Regio- and Stereoselective Hydrosilylation of Unsymmetrical Alkynes Catalyzed by a Well-Defined, Low-Valent Cobalt Catalyst

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• 作者：Alejandro Rivera-Hernández ; Brendan J. Fallon ; Sandrine Ventre ; Cédric Simon ; Marie-Hélène Tremblay ; Geoffrey Gontard ; Etienne Derat ; Muriel Amatore ; Corinne Aubert ; Marc Petit
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：September 2, 2016
• 年：2016
• 卷：18
• 期：17
• 页码：4242-4245
• 全文大小：418K
• 年卷期：0
• ISSN：1523-7052

文摘

Herein, the use of a well-defined low-valent cobalt(I) catalyst [HCo(PMe₃)₄] capable of performing the highly regio- and stereoselective hydrosilylation of internal alkynes is reported. The reaction can be applied to a variety of hydrosilanes, symmetrical and unsymmetrical alkynes, giving in many cases a single hydrosilylation isomer. Experimental and theoretical studies suggest the key step to be a hydro-cobaltation and that the reaction proceeds through a classical Chalk–Harrod mechanism.