Crystal Structures of Cisplatin Bound to a Human Copper Chaperone
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- 作者：Amie K. Boal ; Amy C. Rosenzweig
- 刊名：Journal of the American Chemical Society
- 出版年：2009
- 出版时间：October 14, 2009
- 年：2009
- 卷：131
- 期：40
- 页码：14196-14197
- 全文大小：119K
- 年卷期：v.131,no.40(October 14, 2009)
- ISSN：1520-5126
文摘
Copper trafficking proteins, including the chaperone Atox1 and the P1B-type ATPase ATP7B, have been implicated in cellular resistance to the anticancer drug cisplatin. We have determined two crystal structures of cisplatin-Atox1 adducts that reveal platinum coordination by the conserved CXXC copper-binding motif. Direct interaction of cisplatin with this functionally relevant site has significant implications for understanding the molecular basis for resistance mediated by copper transport pathways.