Stereochemical Study of Sphingosine by Vibrational Circular Dichroism
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- 作者：Atsufumi Nakahashi ; Ananda Kumar C. Siddegowda ; Mostafa A. S. Hammam ; Siddabasave Gowda B. Gowda ; Yuta Murai ; Kenji Monde
- 刊名：Organic Letters
- 出版年：2016
- 出版时间：May 20, 2016
- 年：2016
- 卷：18
- 期：10
- 页码：2327-2330
- 全文大小：310K
- 年卷期：0
- ISSN：1523-7052
文摘
Vibrational circular dichroism (VCD) was first applied to the stereochemical analysis of sphingosine. VCD patterns derived from the C═C stretch as well as other mid-infrared (IR) regions were practical markers to discriminate all the stereoisomers of intact sphingosine. Glutaraldehyde was found as an excellent derivatizing reagent for sphingosine which improves its solubility in VCD-friendly nonpolar solvents such as chloroform and enhances the VCD intensities by forming a rigid cyclized structure.