Rolloamides A and B, Cytotoxic Cyclic Heptapeptides Isolated from the Caribbean Marine Sponge Eurypon laughlini
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- 作者：David E. Williams ; Ker Yu ; Hans W. Behrisch ; Rob Van Soest ; Raymond J. Andersen
- 刊名：Journal of Natural Products
- 出版年：2009
- 出版时间：July 24, 2009
- 年：2009
- 卷：72
- 期：7
- 页码：1253-1257
- 全文大小：126K
- 年卷期：v.72,no.7(July 24, 2009)
- ISSN：1520-6025
文摘
Two cyclic heptapeptides, rolloamides A (1) and B (2), have been isolated from the Dominican marine sponge Eurypon laughlini. The structures of 1 and 2 were elucidated by a combination of spectroscopic analyses and chemical degradation. Rolloamide A (1), which was found to exist as two distinct conformers in C5D5N, exhibits growth suppressive activity against a panel of histologically diverse cancer cell lines.