Nahuoic Acid A Produced by a Streptomyces sp. Isolated From a Marine Sediment Is a Selective SAM-Competitive Inhibitor of the Histone Methyltransferase SETD8
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- 作者：David E. Williams ; Doralyn S. Dalisay ; Fengling Li ; James Amphlett ; Wisanu Maneerat ; Miguel Angel Garcia Chavez ; Yan Alexander Wang ; Teatulohi Matainaho ; Wenyu Yu ; Peter J. Brown ; Cheryl H. Arrowsmith ; Masoud Vedadi ; Raymond J. Andersen
- 刊名：Organic Letters
- 出版年：2013
- 出版时间：January 18, 2013
- 年：2013
- 卷：15
- 期：2
- 页码：414-417
- 全文大小：243K
- 年卷期：v.15,no.2(January 18, 2013)
- ISSN：1523-7052
文摘
The histone lysine monomethyltransferase SETD8 is an epigenetic regulator of cell cycle progression. Nahuoic acid A (1), a polyketide produced in culture by a Streptomyces sp. obtained from a tropical marine sediment, is the first known selective SAM-competitive inhibitor of SETD8. The structure of nahuoic acid A (1) has been elucidated by chemical transformation and detailed analysis of spectroscopic data.