Development of a Chemoenzymatic Route to (R)-Allyl-(3-amino-2-(2-methylbenzyl)propyl)carbamate

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• 作者：Marika Lindhagen ; Tomas Klingstedt ; S?ren M. Andersen ; Keith R. Mulholland ; Laura Tinkler ; Gary McPheators ; Richard Chubb
• 刊名：Organic Process Research & Development
• 出版年：2016
• 出版时间：January 15, 2016
• 年：2016
• 卷：20
• 期：1
• 页码：65-69
• 全文大小：272K
• ISSN：1520-586X

文摘

A chemoenzymatic route to (R)-allyl-(3-amino-2-(2-methylbenzyl)propyl)carbamate (1-(R)) has been developed on a kilogram scale. The key intermediate, 2-(2-methylbenzyl)propane-1,3-diamine 4, was isolated as a tartrate salt in a three-step sequence starting from 2-methylbenzyl chloride. The subsequent lipase-catalyzed desymmetrization was optimized, and 1-(R) was isolated as the mallcaps">d-tartrate salt.