OPHA (Oxidation鈥揚asserini鈥揌ydrolysis鈥揂lkylation) Strategy: a Four-Step, One-Pot Improvement of the Alkylative Passerini Reaction

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• 作者：Fabio De Moliner ; Martina Bigatti ; Luca Banfi ; Renata Riva ; Andrea Basso
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：April 18, 2014
• 年：2014
• 卷：16
• 期：8
• 页码：2280-2283
• 全文大小：250K
• 年卷期：v.16,no.8(April 18, 2014)
• ISSN：1523-7052

文摘

Multicomponent reactions are often recognized for their efficiency and convergency, if compared with multistep organic synthesis. Nevertheless, we here demonstrate that a four-step-one-pot approach (named OPHA strategy for the initials of the four steps involved) is not only able to afford compounds that could not be obtained by an alkylative Passerini reaction but also capable of generating them with minimal loss of atoms and high operational simplicity, as in a typical multicomponent approach.