Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [45Ti](salan)Ti(dipic)

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• 作者：Gregory W. Severin ; Carsten H. Nielsen ; Andreas I. Jensen ; Jesper Fonslet ; Andreas Kj忙r ; Fedor Zhuravlev
• 刊名：Journal of Medicinal Chemistry
• 出版年：2015
• 出版时间：September 24, 2015
• 年：2015
• 卷：58
• 期：18
• 页码：7591-7595
• 全文大小：318K
• ISSN：1520-4804

文摘

We present a novel solid-phase based ⁴⁵Ti radiolabeling methodology and the implementation of ⁴⁵Ti-PET in titanium-based antineoplastics using the showcase compound [⁴⁵Ti](salan)Ti(dipic). This development is intended to allow elucidation of the biodistribution and pharmacokinetics of promising new Ti-based therapeutics.