Iron-Catalyzed Cross-Coupling of N-Heterocyclic Chlorides and Bromides with Arylmagnesium Reagents

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• 作者：Olesya M. Kuzmina ; Andreas K. Steib ; Dietmar Flubacher ; Paul Knochel
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：September 21, 2012
• 年：2012
• 卷：14
• 期：18
• 页码：4818-4821
• 全文大小：228K
• 年卷期：v.14,no.18(September 21, 2012)
• ISSN：1523-7052

文摘

A simple, practical iron salt catalyzed procedure allows fast cross-couplings of N-heterocyclic chlorides and bromides with various electron-rich and -poor arylmagnesium reagents. A solvent mixture of THF and tBuOMe is found to be essential for achieving high yields mainly by avoiding homocoupling side reactions.