Enantioselective Allylation of 伪,尾-Unsaturated Aldehydes with Allyltrichlorosilane Catalyzed by METHOX

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• 作者：Andrei V. Malkov ; Maciej Bar艂ó ; g ; Yvonne Jewkes ; Jir虒í ; Mikus虒ek ; Pavel Koc虒ovsky虂
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：June 3, 2011
• 年：2011
• 卷：76
• 期：11
• 页码：4800-4804
• 全文大小：807K
• 年卷期：v.76,no.11(June 3, 2011)
• ISSN：1520-6904

文摘

伪,尾-Unsaturated aldehydes 6a鈥搄 undergo an enantioselective allylation with allylic trichlorosilanes 2a,b in the presence of METHOX (4) as a Lewis basic catalyst (鈮?0 mol %) to produce the homoallylic alcohols 7a鈥?i>l at good to high enantioselectivity (83鈥?6% ee). This study shows that the reactivity scope of METHOX can be extended from aromatic to nonaromatic aldehydes.