Development of the Direct Suzuki鈥揗iyaura Cross-Coupling of Primary B-Alkyl MIDA-boronates and Aryl Bromides

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• 作者：Jeffrey D. St. Denis ; Conor C. G. Scully ; C. Frank Lee ; Andrei K. Yudin
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：March 7, 2014
• 年：2014
• 卷：16
• 期：5
• 页码：1338-1341
• 全文大小：328K
• 年卷期：v.16,no.5(March 7, 2014)
• ISSN：1523-7052

文摘

The development of a palladium-catalyzed sp³鈥搒p² Suzuki鈥揗iyaura cross-coupling of B-alkyl-N-methyliminodiacetyl (B-alkyl MIDA) boronates and (hetero)aryl bromides is reported. This transformation is tolerant of a variety of functional groups (F, NO₂, CN, Cl, COCH₃, and CHO). B-Alkyl MIDA boronates allow an efficient cross-coupling reaction directed toward the synthesis of unsymmetrical methylene diaryls as well as alkylated arenes in good to excellent yields.