Magnetic Field Switching of Nanoparticles between Orthogonal Microfluidic Channels

详细信息    查看全文

• 作者：Andrew H. Latham ; Anand N. Tarpara ; Mary Elizabeth Williams
• 刊名：Analytical Chemistry
• 出版年：2007
• 出版时间：August 1, 2007
• 年：2007
• 卷：79
• 期：15
• 页码：5746 - 5752
• 全文大小：373K
• 年卷期：v.79,no.15(August 1, 2007)
• ISSN：1520-6882

文摘

This paper reports on the manipulation of magneticnanoparticles between microfluidic channels by the application of an external magnet. Two orthogonal channelswere prepared using standard PDMS techniques withpressure-driven flow used to deliver the mobile phase. Tostudy the ability to control magnetic nanoparticles withinmicrometer-sized channels, Fe₂O₃, MnFe₂O₄, and Aunanoparticle samples were compared. For the magneticparticles, transfer between flow streams is greatly increased by placing a permanent magnet beneath theintersection of the channels, but no change is observedfor the nonmagnetic Au particles. More nanoparticles aremagnetically transferred into the orthogonal channel asthe solvent flow rate decreases. We demonstrate the abilityto use this technique to perform multiple injections ofplugs of magnetic particles by periodic application of amagnetic field.