Serological Immunoreactivity against Colon Cancer Proteome Varies upon Disease Progression
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- 作者：Lucia De Monte ; Francesca Sanvito ; Stefano Olivieri ; Fiammetta Viganò ; Claudio Doglioni ; Matteo Frasson ; Marco Braga ; Angela Bachi ; Paolo Dellabona ; Maria Pia Protti ; Massimo Alessio
- 刊名：Journal of Proteome Research
- 出版年：2008
- 出版时间：February 2008
- 年：2008
- 卷：7
- 期：2
- 页码：504 - 514
- 全文大小：1229K
- 年卷期：v.7,no.2(February 2008)
- ISSN：1535-3907
文摘
Sera from colon carcinoma patients were used to identify tumor-associated antigens (TAAs) by screening tumor proteome resolved by 2D electrophoresis. A panel of six TAAs eliciting a serological immune response in colorectal cancer was identified, showing a modification in antigen recognition by B cells in patients as a function of colon cancer progression. The expression of these proteins was either confined or increased in tumor as compared to normal mucosa.