Total Syntheses and Biological Evaluation of (卤)-Botryosphaeridione, (卤)-Pleodendione, 4-epi-Periconianone B, and Analogues

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• 作者：Kishor L. Handore ; Prakash D. Jadhav ; Bibhabasu Hazra ; Anirban Basu ; D. Srinivasa Reddy
• 刊名：ACS Medicinal Chemistry Letters
• 出版年：2015
• 出版时间：November 12, 2015
• 年：2015
• 卷：6
• 期：11
• 页码：1117-1121
• 全文大小：449K
• ISSN：1948-5875

文摘

The total syntheses of (卤)-botryosphaeridione, (卤)-pleodendione, (卤)-hoaensieremodione, 4-epi-periconianone B, and their analogues have been accomplished for the first time. All the synthesized target compounds were screened in neural anti-inflammatory assays using LPS induced microglia cells (N9). Among them, compounds 1 and 21 were identified as potential lead compounds for further profiling.