Synthesis and Modification of Functional Poly(lactide) Copolymers: Toward Biofunctional Materials

详细信息    查看全文

• 作者：David E. Noga ; Timothy A. Petrie ; Anjli Kumar ; Marcus Weck ; André ; s J. Garcí ; a ; David M. Collard
• 刊名：Biomacromolecules
• 出版年：2008
• 出版时间：July 2008
• 年：2008
• 卷：9
• 期：7
• 页码：2056 - 2062
• 全文大小：810K
• 年卷期：v.9,no.7(July 2008)
• ISSN：1526-4602

文摘

A polylactide copolymer with pendant benzyloxy groups has been synthesized by the copolymerization of a benzyl-ether substituted monomer with lactide. Debenzylation of the polymer to provide pendant hydroxyl groups followed by modification with succinic anhydride affords the corresponding carboxylic acid functionalized copolymer that is amenable to standard carbodiimide coupling conditions to attach amine-containing biological molecules. An amino-substituted biotin derivative was coupled to the carboxyl functional groups of copolymer films as proof-of-concept. In a demonstration of the function of these new materials, an RGD-containing peptide sequence was tethered to copolymer films at various densities and was shown to enhance the adhesion of epithelial cells. This strategy provides the opportunity for the attachment of a variety of ligands, allowing for the fabrication of a versatile class of biodegradable, biocompatible materials.