Organocatalytic Enantioselective Nucleophilic Vinylic Substitution by -Substituted-<img src="http://pubs.acs.org/images/gifchars/alp

详细信息    查看全文

• 作者：Mark Bell ; Thomas B. Poulsen ; Karl Anker J<img src="http ; //pubs.acs.org/images/gifchars/oslash.gif" border="0">rgensen
• 刊名：Journal of Organic Chemistry
• 出版年：2007
• 出版时间：April 13, 2007
• 年：2007
• 卷：72
• 期：8
• 页码：3053 - 3056
• 全文大小：103K
• 年卷期：v.72,no.8(April 13, 2007)
• ISSN：1520-6904

文摘

jo070024pn00001>

<IMG SRC="/isubscribe/journals/joceah/72/i08/figures/jo070024pn00001.gif" ALIGN="left" HSPACE=5>

The organocatalytic enantioselective formation of vinyl-substituted all-carbon quaternary stereocentersvia nucleophilic vinylic substitution by -substituted--cyanoacetates is presented. The reaction proceedswell for different -substituted--cyanoacetates and -chloroalkenones using a dimeric cinchona alkaloidphase-transfer catalyst giving the products in good yield and with enantioselectivities up to 98% ee.