Atropisomerism-Induced Facial Selectivity in Nitrile Oxide Cycloadditions with 5-Methylenehydantoins

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• 作者：Anna M. Said ; G. Paul Savage
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：August 19, 2011
• 年：2011
• 卷：76
• 期：16
• 页码：6946-6950
• 全文大小：775K
• 年卷期：v.76,no.16(August 19, 2011)
• ISSN：1520-6904

文摘

N-Aryl 5-methylenehydantoins underwent nitrile oxide cycloaddition with benzonitrile oxide to give 5-spiro isoxazoline adducts with complete regioselectivity. Atropisomerism around the N-aryl bond also led to facial selectivity in these cycloadditions.