Catalytic Enantioselective Synthesis of Naturally Occurring Butenolides via Hetero-Allylic Alkylation and Ring Closing Metathesis

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• 作者：Bin Mao ; Koen Geurts ; Mart铆n Fa帽an谩s-Mastral ; Anthoni W. van Zijl ; Stephen P. Fletcher ; Adriaan J. Minnaard ; Ben L. Feringa
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：March 4, 2011
• 年：2011
• 卷：13
• 期：5
• 页码：948-951
• 全文大小：723K
• 年卷期：v.13,no.5(March 4, 2011)
• ISSN：1523-7052

文摘

An efficient catalytic asymmetric synthesis of chiral 纬-butenolides was developed based on the hetero-allylic asymmetric alkylation (h-AAA) in combination with ring closing metathesis (RCM). The synthetic potential of the h-AAA-RCM protocol was illustrated with the facile synthesis of (鈭?-whiskey lactone, (鈭?-cognac lactone, (鈭?-nephrosteranic acid, and (鈭?-roccellaric acid.