In Situ Deposition of PLGA Nanofibers via Solution Blow Spinning

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• 作者：Adam M. Behrens ; Brendan J. Casey ; Michael J. Sikorski ; Kyle L. Wu ; Wojtek Tutak ; Anthony D. Sandler ; Peter Kofinas
• 刊名：ACS Macro Letters
• 出版年：2014
• 出版时间：March 18, 2014
• 年：2014
• 卷：3
• 期：3
• 页码：249-254
• 全文大小：537K
• 年卷期：v.3,no.3(March 18, 2014)
• ISSN：2161-1653

文摘

Nanofiber mats and scaffolds have been widely investigated for biomedical applications. Commonly fabricated using electrospinning, nanofibers are generated ex situ using an apparatus that requires high voltages and an electrically conductive target. We report the use of solution blow spinning to generate conformal nanofiber mats/meshes on any surface in situ, utilizing only a commercial airbrush and compressed CO₂. Solution and deposition conditions of PLGA nanofibers were optimized and mechanical properties characterized with dynamic mechanical analysis. Nanofiber mat degradation was monitored for morphologic and molecular weight changes in vitro. Biocompatibility of the direct deposition of nanofibers onto two cell lines was demonstrated in vitro and interaction with blood was qualitatively assessed with scanning electron microscopy. A pilot animal study illustrated the wide potential of this technique across multiple surgical applications, including its use as a surgical sealant, hemostatic, and buttress for tissue repair.