Chemoenzymatic Synthesis of the Human CD52 and CD24 Antigen Analogues

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• 作者：Zhimeng Wu ; Xueqing Guo ; Guofeng Gu ; Zhongwu Guo
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：November 15, 2013
• 年：2013
• 卷：15
• 期：22
• 页码：5906-5908
• 全文大小：218K
• 年卷期：v.15,no.22(November 15, 2013)
• ISSN：1523-7052

文摘

Analogs of the human CD52 and CD24 antigens carrying the common core structure of glycosylphosphatidylinositol (GPI) anchors and the intact polypeptide sequences of CD52 and CD24 were chemoenzymatically synthesized. CD52 and CD24 proteins were obtained by solid-phase peptide synthesis and then coupled to chemically synthesized GPI anchors under the influence of a bacterial enzyme, sortase A, to afford the target molecules in good yields.