A Practical and General Synthesis of Unsymmetrical Terphenyls

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• 作者：Jose M. Antelo Miguez ; Luis Angel Adrio ; Antonio Sousa-Pedrares ; Jose M. Vila ; King Kuok (Mimi) Hii
• 刊名：Journal of Organic Chemistry
• 出版年：2007
• 出版时间：September 28, 2007
• 年：2007
• 卷：72
• 期：20
• 页码：7771 - 7774
• 全文大小：114K
• 年卷期：v.72,no.20(September 28, 2007)
• ISSN：1520-6904

文摘

A synthetic procedure was developed that enables sequentialchemoselective Suzuki-Miyaura cross-coupling of chlorobromobenzene with arylboronic acids. The first coupling isachieved at room temperature using a ligandless palladiumcatalyst. The chlorobiaryl product can then be subjecteddirectly to the second coupling, facilitated by the SPhosligand. Using this methodology, parallel synthesis of 32unsymmetrical o-, m-, and p-terphenyl compounds wasaccomplished in good to excellent overall yields.