Stable Polymer Micelles Formed by Metal Coordination

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• 作者：Junyou Wang ; Martien A. Cohen Stuart ; Antonius T. M. Marcelis ; Mathieu Colomb-Delsuc ; Sijbren Otto ; Jasper van der Gucht
• 刊名：Macromolecules
• 出版年：2012
• 出版时间：September 11, 2012
• 年：2012
• 卷：45
• 期：17
• 页码：7179-7185
• 全文大小：383K
• 年卷期：v.45,no.17(September 11, 2012)
• ISSN：1520-5835

文摘

Metal-containing polymer micelles have attracted much attention due to their potential for medical and nanotechnological applications. In this paper, we present a method to prepare stable metal-containing polymer micelles. A diblock copolymer poly(4-vinylpyridine)-b-poly(ethylene oxide) (P4VP₄₈-b-PEO₁₉₃) with terdendate ligand groups grafted to the PVP block is synthesized. Added metal ions cross-link the ligand-carrying blocks together, while the hydrophilic block stabilizes the formed coordination complex, leading to the formation of micelles. The structure and stability of the formed micelles are investigated by light scattering and cyro-TEM. The strong coordination bonds provide high stability of the micelles: adding salt or EDTA hardly affects the formed micelles.