Hybrid Nanospheres Formed by Intermixed Double-Hydrophilic Block Copolymer Poly(ethylene oxide)-block-poly(2-ethyloxazoline) with High Content of Metallacarboranes

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• 作者：Vladim铆r 膸or膹ovi膷 ; Mariusz Uchman ; Karel Proch谩zka ; Alexander Zhigunov ; Josef Ple拧til ; Antti Nyk盲nen ; Janne Ruokolainen ; Pavel Mat臎j铆膷ek
• 刊名：Macromolecules
• 出版年：2013
• 出版时间：September 10, 2013
• 年：2013
• 卷：46
• 期：17
• 页码：6881-6890
• 全文大小：488K
• 年卷期：v.46,no.17(September 10, 2013)
• ISSN：1520-5835

文摘

In search for biocompatible hydrophilic polymers suitable for preparation of delivery systems of boron cluster compounds with high loading capacity, we studied the interaction of metallacarborane sodium [3-cobalt(III) bis(1,2-dicarbollide)] with poly(2-ethyloxazoline) (PEOX) and with a double-hydrophilic block copolymer poly(ethylene oxide)-block-poly(2-ethyloxazoline) (PEO鈥揚EOX) in aqueous solutions by a combination of scattering, microscopy, spectroscopy, and thermochemistry techniques. The paper is a contribution to our long-time study of novel hybrid nanostructures based on hydrophilic polymer鈥搈etallacarborane complexes. PEOX homopolymer interacts with metallacarborane, resulting in a water-soluble, negatively charged complex. In the case of diblock copolymer PEO鈥揚EOX, both blocks interact with metallacarborane via dihydrogen bonds and participate in the formation of hybrid gel-like nanostructures in 0.1 M NaCl aqueous solutions, which are unique as compared to other boron cluster-containing polymeric systems. The stable spherical nanoparticles with high metallacarborane content do not adopt core/shell structure, which has been observed for other PEO-containing double hydrophilic block copolymers [Macromolecules 2009, 42, 4829], but the nanospheres are homogeneous. They contain intermixed PEO and PEOX blocks, which are cross-linked by metallacarborane molecules. The size of the nanospheres depends on a preparation protocol, while their inner structure does not. Besides the detailed study on PEO鈥揚EOX/metallacarborane system, a high application potential of PEO鈥揚EOX complexes with several metallacarborane-based drugs is also shown. The study clearly demonstrates that PEOX is suitable polymer for designing novel hybrid nanostructures.