Ba-Catalyzed Direct Mannich-Type Reactions of a ,

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• 作者：Akitake Yamaguchi ; Naohiro Aoyama ; Shigeki Matsunaga ; Masakatsu Shibasaki
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：August 16, 2007
• 年：2007
• 卷：9
• 期：17
• 页码：3387 - 3390
• 全文大小：90K
• 年卷期：v.9,no.17(August 16, 2007)
• ISSN：1523-7052

文摘

Barium-catalyzed direct Mannich-type reactions of a ,-unsaturated ester are described. The Ba-catalyst not only promoted the Mannich-typereactions, but also isomerized Mannich adducts to afford -methyl aza-Morita-Baylis-Hillman-type products in 61-88% yield from variousaryl, heteroaryl, and alkyl imines. Preliminary trials on enantioselective variants with a chiral biaryldiol ligand gave products in up to 80% ee.