Photoresponsive Nanogels Formed by the Self-Assembly of Spiropyrane-Bearing Pullulan That Act as Artificial Molecular Chaperones

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• 作者：Tai Hirakura ; Yuta Nomura ; Yasuhiro Aoyama ; and Kazunari Akiyoshi
• 刊名：Biomacromolecules
• 出版年：2004
• 出版时间：September 2004
• 年：2004
• 卷：5
• 期：5
• 页码：1804 - 1809
• 全文大小：78K
• 年卷期：v.5,no.5(September 2004)
• ISSN：1526-4602

文摘

Novel photoresponsive nanogels were prepared by the self-assembly of spiropyrane-bearing pullulan (SpP).The solution properties of the nanogels could be controlled by photostimulation via isomerization betweenhydrophobic spiropyrane and hydrophilic merocyanine. The molecular chaperone-like activity of the nanogelsin protein refolding was investigated. The activity of citrate synthase significantly increased when theamphiphilicity of SpP nanogels was switched by photostimulation.