Synthesis, Characterization, and in Vitro Cytotoxicity of Some Gold(I) and Trans Platinum(II) Thionate Complexes Containing Water-Soluble PTA and DAPTA Ligands. X-ray Crystal Structures of [Au(SC

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• 作者：Susana Miranda ; Elena Vergara ; Fabian Mohr ; Dick de Vos ; Elena Cerrada ; Ar&#xe1 ; nzazu Mend&#xed ; a ; Mariano Laguna
• 刊名：Inorganic Chemistry
• 出版年：2008
• 出版时间：July 7, 2008
• 年：2008
• 卷：47
• 期：13
• 页码：5641 - 5648
• 全文大小：301K
• 年卷期：v.47,no.13(July 7, 2008)
• ISSN：1520-510X

文摘

A series of gold(I) and platinum(II) complexes of the type [Au(SR)(P)] and trans-[Pt(SR)₂(P)₂] [SR = 2-thiopyridine (SPy), 2-thiopyrimidine (SPyrim); P = 1,3,5-triaza-7-phosphaadamantane (PTA), 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane (DAPTA)] were prepared and characterized, and their in vitro cytotoxicities against a panel of seven human cancer cell lines were evaluated. The highly water soluble gold(I) complexes [Au(SR)(P)] [P = PTA and SR = SPy (1), SPyrim (2); P = DAPTA and SR = SPy (3), SPyrim (4)] showed low cytotoxicity, while the platinum(II) complexes trans-[Pt(SR)₂(P)₂] [P = PTA and SR = SPyrim (5), SPy (6); P = DAPTA and SR = SPyrim (7), SPy (8)] demonstrated potent cytotoxicity for ovarian, colon, renal, and melanoma cancer cell lines on the basis of a comparison with ID₅₀ values for some established cytotoxic drugs. Single crystals of 2, 5, 6, and 8 suitable for X-ray structural characterization were obtained, and the study revealed the trans configuration for 5, 6, and 8 in their solid states.