Arylethenylbenzofuroxan Derivatives as Drugs for Chagas Disease: Multigram Batch Synthesis using a Wittig−Boden Process

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• 作者：Williams Porcal ; Alicia Merlino ; Mariana Boiani ; Alejandra Gerpe ; Mercedes Gonz&#xe1 ; lez ; Hugo Cerecetto
• 刊名：Organic Process Research & Development
• 出版年：2008
• 出版时间：March 2008
• 年：2008
• 卷：12
• 期：2
• 页码：156 - 162
• 全文大小：156K
• 年卷期：v.12,no.2(March 2008)
• ISSN：1520-586X

文摘

In the present work, we developed robust processes for the preparation of new antitrypanosomal benzofuroxans, E and Z isomers of 5-arylethenylbenzo[1,2-c]1,2,5-oxadiazole N¹-oxide 1–6, in multigram batch through Wittig−Boden conditions as the key synthetic step. In these conditions, the generation of the benzofurazans, as secondary byproduct, was minimized.