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• 作者：Satoru Arimitsu ; Gerald B. Hammond
• 刊名：Journal of Organic Chemistry
• 出版年：2006
• 出版时间：October 27, 2006
• 年：2006
• 卷：71
• 期：22
• 页码：8665 - 8668
• 全文大小：89K
• 年卷期：v.71,no.22(October 27, 2006)
• ISSN：1520-6904

文摘

An indium-mediated Barbier-type reaction of difluoropropargyl bromide with several aldehydes in aqueous media wasenhanced by a catalytic amount of a lanthanide triflate (5mol %). The reaction gave the corresponding ,-difluorohomopropargyl alcohols with high regioselectivity. The [2+ 2 + 2] alkyne cyclotrimerization of ,-difluorohomopropargyl alcohols with monosubstituted acetylenes produced4,4-difluoroisochromans in good yields with moderate regioselectivity.