Additive- and Metal-Free, Predictably 1,2- and 1,3-Regioselective, Photoinduced Dual C–H/C–X Borylation of Haloarenes

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• 作者：Adelphe M. Mfuh ; Vu T. Nguyen ; Bhuwan Chhetri ; Jessica E. Burch ; John D. Doyle ; Vladimir N. Nesterov ; Hadi D. Arman ; Oleg V. Larionov
• 刊名：Journal of the American Chemical Society
• 出版年：2016
• 出版时间：July 13, 2016
• 年：2016
• 卷：138
• 期：27
• 页码：8408-8411
• 全文大小：375K
• 年卷期：0
• ISSN：1520-5126

文摘

We report herein a simple, additive- and metal-free, photoinduced, dual C–H/C–X borylation of chloro-, bromo-, and iodoarenes. The reaction produces 1,2- and 1,3-diborylarenes on gram scales under batch and continuous flow conditions. The regioselectivity of the dual C–H/C–X borylation is determined by the solvent and the substituents in the parent haloarenes.