Synthetic Route to Dinuclear Platinum(II) Complexes [{trans-PtCl(NH3)2}2(μ-L)]2+ (L = Aliphatic or Heterocyclic Diamine) as Potential Antitumor
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- 作者：Claude Chopard ; Christine Lenoir ; Silvia Rizzato ; Michel Vidal ; Jorma Arpalahti ; Laure Gabison ; Alberto Albinati ; Christiane Garbay ; Jiř ; í ; Kozelka
- 刊名：Inorganic Chemistry
- 出版年：2008
- 出版时间：October 20, 2008
- 年：2008
- 卷：47
- 期：20
- 页码：9701-9705
- 全文大小：149K
- 年卷期：v.47,no.20(October 20, 2008)
- ISSN：1520-510X
文摘
A simple and efficient method for the synthesis of potentially antitumor-active dinuclear platinum complexes of the general formula [{trans-PtCl(NH3)2}2(μ-L)](n+2)+ (L = aliphatic or heterocyclic diamine; n = charge of L) is presented. The procedure is based on the mutual in situ activation of trans-[PtCl(OH)(NH3)2] and the linker L in the form of a diammonium salt. This synthetic pathway yielded the Farrell compound [{trans-PtCl(NH3)2}2{μ-NH2(CH2)6NH2}]Cl2 (BBR3005) in quantitative yield. Using the same procedure, we prepared the new pyrazolate-bridged compound [{trans-PtCl(NH3)2}2(μ-pz)]Cl, determined its X-ray structure, and tested its cytotoxicity against three wild-type and one cisplatin-resistant cell lines.