Enantioselective Organocatalytic Conjugate Reduction of β-Azole-Containing α,β-Unsaturated Aldehydes

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• 作者：Thomas J. Hoffman ; Jyotirmayee Dash ; James H. Rigby ; Stellios Arseniyadis ; Janine Cossy
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：July 2, 2009
• 年：2009
• 卷：11
• 期：13
• 页码：2756-2759
• 全文大小：166K
• 年卷期：v.11,no.13(July 2, 2009)
• ISSN：1523-7052

文摘

β-Azole-containing α,β-unsaturated aldehydes were successfully reduced under highly enantioselective organocatalytic transfer hydrogenation conditions. The products were obtained in good yields and up to 94% optical purity. This simple process was successfully applied to the synthesis of the C7−C14 fragment of ulapualide A, a natural product which exhibits promising antitumor activity.