Realization and Properties of Biochemical-Computing Biocatalytic XOR Gate Based on Enzyme Inhibition by a Substrate

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• 作者：Jan Hala虂mek ; Vera Bocharova ; Mary A. Arugula ; Guinevere Strack ; Vladimir Privman ; Evgeny Katz
• 刊名：Journal of Physical Chemistry B
• 出版年：2011
• 出版时间：August 18, 2011
• 年：2011
• 卷：115
• 期：32
• 页码：9838-9845
• 全文大小：932K
• 年卷期：v.115,no.32(August 18, 2011)
• ISSN：1520-5207

文摘

We consider a realization of the XOR logic gate in a process biocatalyzed by an enzyme which can be inhibited by a substrate when the latter is inputted at large enough concentrations. A model is developed for describing such systems in an approach suitable for evaluation of the analog noise amplification properties of the gate. The obtained data are fitted for gate quality evaluation within the developed model, and we discuss aspects of devising XOR gates for functioning in 鈥渂iocomputing鈥?systems utilizing biomolecules for information processing.