A Mild and Regioselective Method for -Bromination of align="midd

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• 作者：Abu T. Khan ; Md Ashif Ali ; Papori Goswami ; Lokman H. Choudhury
• 刊名：Journal of Organic Chemistry
• 出版年：2006
• 出版时间：November 10, 2006
• 年：2006
• 卷：71
• 期：23
• 页码：8961 - 8963
• 全文大小：115K
• 年卷期：v.71,no.23(November 10, 2006)
• ISSN：1520-6904

文摘

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Bromodimethylsulfonium bromide has been found to be aneffective and regioselective reagent for -monobrominationof -keto esters and 1,3-diketones. A wide variety of -ketoesters and 1,3-diketones undergo chemoselective -monobromination with excellent yields at 0-5 C or roomtemperature. The notable advantages of this protocol are noneed of chromatographic separation, use of less hazardousreagent than molecular bromine, and no added base, Lewisacid, or other catalyst.