Copper-Mediated Synthesis of Substituted 2-Aryl-N-benzylbenzimidazoles and 2-Arylbenzoxazoles via C鈥揌 Functionalization/C鈥揘/C鈥揙 Bond Formation

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• 作者：Murali Mohan Guru ; Md Ashif Ali ; Tharmalingam Punniyamurthy
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：July 1, 2011
• 年：2011
• 卷：76
• 期：13
• 页码：5295-5308
• 全文大小：1314K
• 年卷期：v.76,no.13(July 1, 2011)
• ISSN：1520-6904

文摘

An efficient method for the transformation of N-benzyl bisarylhydrazones and bisaryloxime ethers to functionalized 2-aryl-N-benzylbenzimidazoles and 2-arylbenzoxazoles is described. The protocol involves a copper(II)-mediated cascade C鈥揌 functionalization/C鈥揘/C鈥揙 bond formation under neutral conditions. Substrates having either electron-donating or -withdrawing substituents undergo the cyclization to afford the target heterocycles at moderate temperature.