Ligand-Free Copper-Catalyzed Synthesis of Substituted Benzimidazoles, 2-Aminobenzimidazoles, 2-Aminobenzothiazoles, and Benzoxazoles
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- 作者：Prasenjit Saha ; Tamminana Ramana ; Nibadita Purkait ; Md Ashif Ali ; Rajesh Paul ; Tharmalingam Punniyamurthy
- 刊名：Journal of Organic Chemistry
- 出版年：2009
- 出版时间：November 20, 2009
- 年：2009
- 卷：74
- 期：22
- 页码：8719-8725
- 全文大小：1042K
- 年卷期：v.74,no.22(November 20, 2009)
- ISSN：1520-6904
文摘
The synthesis of substituted benzimidazoles, 2-aminobenzimidazoles, 2-aminobenzothiazoles, and benzoxazoles is described via intramolecular cyclization of o-bromoaryl derivatives using copper(II) oxide nanoparticles in DMSO under air. The procedure is experimentally simple, general, efficient, and free from addition of external chelating ligands. It is a heterogeneous process and the copper(II) oxide nanoparticles can be recovered and recycled without loss of activity.