Cespihypotins Q−V, Verticillene Diterpenoids from Cespitularia hypotentaculata

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• 作者：Ya-Ching Shen ; Kuang-Liang Lo ; Yao-Haur Kuo ; Yuh-Chi Kuo ; Chung-Hsiung Chen ; Ashraf T. Khalil
• 刊名：Journal of Natural Products
• 出版年：2008
• 出版时间：December 26, 2008
• 年：2008
• 卷：71
• 期：12
• 页码：1993-1997
• 全文大小：169K
• 年卷期：v.71,no.12(December 26, 2008)
• ISSN：1520-6025

文摘

Chemical investigation of the soft coral Cespitularia hypotentaculata resulted in the isolation of six new diterpenes, cespihypotins Q−V (1−6). The new metabolites comprised five verticillane-type diterpenes and one nor-verticillane derivative. Their structures were determined through detailed spectroscopic analyses, especially HRESIMS and 2D NMR techniques. The relative configuration was deduced by interpretation of NOESY spectra. Cespihypotin T (4) exhibited significant cytotoxic activity against human Daoy and WiDr tumor cell lines.