Catalytic Asymmetric Addition of Aldehydes to Oxocarbenium Ions: A Dual Catalytic System for the Synthesis of Chromenes

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• 作者：Magnus Rueping ; Chandra M. R. Volla ; Iuliana Atodiresei
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：September 7, 2012
• 年：2012
• 卷：14
• 期：17
• 页码：4642-4645
• 全文大小：239K
• 年卷期：v.14,no.17(September 7, 2012)
• ISSN：1523-7052

文摘

A synergistic catalytic system for the first asymmetric addition of aldehydes to in situ generated prochiral oxocarbenium ions has been developed. The dual catalytic protocol allows the simultaneous activation of both electrophile and nucleophile and provides access to a variety of valuable chiral 2H-chromenes with excellent enantioselectivities.