Three-Component Coupling Using Arynes and Aminosilanes for ortho-Selective Double Functionalization of Aromatic Skeletons
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- 作者：Takami Morishita ; Hiroyuki Fukushima ; Hiroto Yoshida ; Joji Ohshita ; Atsutaka Kunai
- 刊名：Journal of Organic Chemistry
- 出版年：2008
- 出版时间：July 18, 2008
- 年：2008
- 卷：73
- 期：14
- 页码：5452 - 5457
- 全文大小：234K
- 年卷期：v.73,no.14(July 18, 2008)
- ISSN：1520-6904
文摘
Arynes were found to couple with aminosilanes and carbonyl compounds in the presence of benzoic acid to provide 2-aminobenzhydrols. Sulfonylimines could also be applied to the reaction, enabling amino and aminomethyl moieties to be incorporated into contiguous positions of aromatic skeletons. Only a small amount of the three-component coupling product was obtained in the absence of benzoic acid, which confirms its vital role in the present reaction.