Polyhydroxy Cyclohexanols from a Dendrodochium sp. Fungus Associated with the Sea Cucumber Holothuria nobilis Selenka
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- 作者：Dong-Xiao Xu ; Peng Sun ; Tibor Kurt谩n ; Attila M谩ndi ; Hua Tang ; Baoshu Liu ; William H. Gerwick ; Zhi-Wei Wang ; Wen Zhang
- 刊名：Journal of Natural Products
- 出版年：2014
- 出版时间：May 23, 2014
- 年：2014
- 卷：77
- 期：5
- 页码：1179-1184
- 全文大小：332K
- 年卷期：v.77,no.5(May 23, 2014)
- ISSN：1520-6025
文摘
Four cyclohexanol analogues, dendrodochols A鈥揇 (1鈥?b>4), were isolated from a Dendrodochium sp. fungus associated with the sea cucumber Holothuria nobilis Selenka collected from the South China Sea. The structures were elucidated by means of detailed spectroscopic analysis. The absolute configurations were assigned using a solution TDDFT/ECD calculation approach and the modified Mosher鈥檚 method. In an in vitro bioassay, these compounds exhibited no growth inhibition activity against the A549 and MG63 cell lines. Dendrodochols 1 and 3 exhibited modest antifungal activity against Candida strains, Cryptococcus neoformans, and Trichophyton rubrum, whereas 2 and 4 showed no activity against the tested strains.