Using Isotopic Fractionation to Link Precursor to Product in the Synthesis of (卤)-Mephedrone: A New Tool for Combating 鈥淟egal High鈥?Drugs

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• 作者：Niamh NicDa茅id ; Wolfram Meier-Augenstein ; Helen F. Kemp ; Oliver B. Sutcliffe
• 刊名：Analytical Chemistry
• 出版年：2012
• 出版时间：October 16, 2012
• 年：2012
• 卷：84
• 期：20
• 页码：8691-8696
• 全文大小：297K
• 年卷期：v.84,no.20(October 16, 2012)
• ISSN：1520-6882

文摘

Several recent deaths in the U.K. have been attributed to 鈥渓egal high鈥?drugs and in particular to (卤)-4-methylmethcathinone ((卤)-mephedrone). Recent literature has begun to focus on the chemical analysis of mephedrone and related substituted cathinones and methcathinones; however, no studies involving the application of stable isotope analysis to these compounds has yet emerged. Such studies have, for example, the potential to provide information linking the final products to a particular precursor by the manufacturer. In this study, the use of stable isotope profiling was explored to provide a possible connection between product and precursor chemicals. Six samples each of mephedrone were prepared using precursor chemicals from two different manufacturers, providing 12 samples in total. Synthesis was via a stable intermediate