A Novel Approach for C–C, C–N, and C–O Bond Formation Reactions: A Facile Synthesis of Benzophenazine, Quinoxaline, and Phenoxazine Derivatives via Ring Opening of Benzoxepines
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- 作者：Bhimapaka China Raju ; Kasagani Veera Prasad ; Gannerla Saidachary ; Balasubramanian Sridhar
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：January 17, 2014
- 年：2014
- 卷：16
- 期：2
- 页码：420-423
- 全文大小：296K
- ISSN：1523-7052
文摘
A new one-pot protocol has been developed for the synthesis of benzophenazine, quinoxaline, and phenoxazine derivatives by the reaction of benzoxepine-4-carboxylates with benzene-1,2-diamines, ethane-1,2-diamine, and 2-aminophenols in the presence of Bi(OTf)3 (5 mol %) under mild conditions in very good yields. The present protocol opens a new way for C鈥揅, C鈥揘, and C鈥揙 bond-formation reactions in a single-step process. The structural assignment was confirmed by X-ray analysis.