Macrocyclic Glycohybrid Toolbox Identifies Novel Antiangiogenesis Agents from Zebrafish Assay
详细信息 查看全文
- 作者：Bhanudas Dasari ; Srinivas Jogula ; Ramdas Borhade ; Sridhar Balasubramanian ; Gayathri Chandrasekar ; Satish Srinivas Kitambi ; Prabhat Arya
- 刊名：Organic Letters
- 出版年：2013
- 出版时间：February 1, 2013
- 年：2013
- 卷：15
- 期：3
- 页码：432-435
- 全文大小：352K
- 年卷期：v.15,no.3(February 1, 2013)
- ISSN：1523-7052
文摘
A practical and modular approach to obtain a diverse set of 14-membered macrocyclic compounds from carbohydrates is developed that utilizes functional groups at C-1 and C-5. The evaluation of this toolbox in various zebrafish assays led to the identification of 2.7f as an antiangiogenesis agent.