Copper-Catalyzed Activation of 伪-Amino Peroxy and Hydroxy Intermediates to Iminium Ion Precursor: An Access to C4-Substituted 3,4-Dihydroquinazolines via Oxidative Cross Coupling Strategy

详细信息    查看全文

• 作者：R. Arun Kumar ; G. Saidulu ; Balasubramanian Sridhar ; Shiuh Tzung Liu ; K. Rajender Reddy
• 刊名：Journal of Organic Chemistry
• 出版年：2013
• 出版时间：October 18, 2013
• 年：2013
• 卷：78
• 期：20
• 页码：10240-10250
• 全文大小：598K
• 年卷期：v.78,no.20(October 18, 2013)
• ISSN：1520-6904

文摘

A simple and straightforward approach to access C4-substituted-3,4-dihydroquinazolines has been achieved, where copper-catalyzed activation of 伪-amino peroxide and hydroxide intermediates to iminium ion precursors has been realized as an important step. Reactions of these intermediates with alkynes, indoles, pyrrole, and silylenol ether afforded the structurally diverse C4-substituted-3,4-dihydroquinazoline derivatives in good yields.