Amide Isosteres of Oroidin: Assessment of Antibiofilm Activity and C. elegans Toxicity
详细信息 查看全文
- 作者：Justin J. Richards ; Samuel Reyes ; Sean D. Stowe ; Ashley T. Tucker ; T. Eric Ballard ; Laura D. Mathies ; John Cavanagh ; Christian Melander
- 刊名：Journal of Medicinal Chemistry
- 出版年：2009
- 出版时间：August 13, 2009
- 年：2009
- 卷：52
- 期：15
- 页码：4582-4585
- 全文大小：757K
- 年卷期：v.52,no.15(August 13, 2009)
- ISSN：1520-4804
文摘
The synthesis and antibiofilm activities of sulfonamide, urea, and thiourea oroidin analogues are described. The most active derivative was able to selectively inhibit P. aeruginosa biofilm development and is also shown to be nontoxic upward of 1 mM to the development of C. elegans in comparison to other similar isosteric analogues and the natural product oroidin.