Calcium Carbonate Nanoplate Assemblies with Directed High-Energy Facets: Additive-Free Synthesis, High Drug Loading, and Sustainable Releasing

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• 作者：Jing Zhang ; Yu Li ; Hao Xie ; Bao-Lian Su ; Bin Yao ; Yixia Yin ; Shipu Li ; Fang Chen ; Zhengyi Fu
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2015
• 出版时间：July 29, 2015
• 年：2015
• 卷：7
• 期：29
• 页码：15686-15691
• 全文大小：426K
• ISSN：1944-8252

文摘

Developing drug delivery systems (DDSs) with high drug-loading capacity and sustainable releasing is critical for long-term chemotherapeutic efficacy, and it still remains challenging. Herein, vaterite CaCO₃ nanoplate assemblies with exposed high-energy {001} facets have been synthesized via a novel, additive-free strategy. The product shows a high doxorubicin-loading capacity (65%); the best of all the CaCO₃-based DDSs so far. Also, the product鈥檚 sustainable releasing performance and its inhibition of the initial burst release, together, endow it with long-term drug efficacy. The work may shed light on exposing directed high-energy facets for rationally designing of a drug delivery system with long-term efficacy.